Non-resectable liver tumors – from palliation to cure



Klinischer Forschungsschwerpunkt (KFSP) der Universität Zürich –
Non-resectable liver tumors  –  from palliation to cure

 


Aims

1. Clinical trial on a highly novel surgical approach to overcome ‘non-resectable’ liver tumors using ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy), a two-step procedure with an as yet unprecedented liver regeneration. Many patients with a variety of tumor, previously felt to be inoperable, can now be cured with this novel approach.
 
2. Translational study in the laboratory to dissect the mechanism of liver regeneration and impact on tumor growth in a newly established mouse model of ALPPS.
 
3. Clinical trials and outcome studies to compare ALPPS with living related liver transplantation in selected groups of patients presenting with non-resectable liver tumors. We will mostly focus on cholangiocarcinoma, for which we have an IRB approved protocol for liver transplantation. We will include in such study diagnostic monitoring of tumor cell seeding and correlate them with outcome (tumor recurrence).

 

Strategies for safer removal of large or multiple liver tumors

 


A Portal vein embolization
to increase the future remnat liver

 

 


B Two-staged hepatectomy
(Adam 2000)

 


C Portal vein embolization (Jaeck 2003) followed by two-staged hepatectomy

 


D Portal vein ligation and two-staged hepatectomy (Clavien 2007)

 

 

E ALPPS (Schlitt 2012). Tumors are highlighted in yellow. The shaded areas indicate the removed part of
the liver.

liver_map  


> Please visit our Website: Non-resectable Liver Tumors - University of Zurich

 

Spezialsprechstunde: Leber, Bauchspeicheldrüse, Gallenwege (Swiss HPB Center Zurich)

Das Swiss HPB-Center Zurich ist spezialisiert auf die umfassende Diagnose und Behandlung von Krankheiten, welche die Leber, die Bauchspeicheldrüse (Pankreas) und die Gallenwege (hepato-pancreatico-biliäre Erkrankungen) betreffen.

Wir legen grossen Wert auf die interdisziplinäre Zusammenarbeit um eine optimale Behandlung zum Wohle unserer Patienten zu ermöglichen. Auch erhalten unsere Patienten Zugang zu den neuesten und innovativsten Therapien auch im Rahmen von klinischen Studien.

Leber/Gallenwege    Pankreas    Swiss HPB Center Zurich    Online-Anmeldung Ärzte/Spitäler

Anmeldung und Auskunft
Tel. +41 44 255 87 54 / 23 44
Fax +41 44 255 89 42
simone.abaecherli@usz.ch

Verantwortliche Kaderärzte
Prof. Dr. P.-A. Clavien
Prof. Dr. H. Petrowsky
PD Dr. K. Horisberger
Dr. C. Oberkofler

Sprechzimmer
UniversitätsSpital Zürich
HPB-Sprechstunde
Ambulante Disposition (AUFN A 370)
Rämistrasse 100
8091 Zürich

Kontaktadresse
UniversitätsSpital Zürich
Klinik für Viszeral- und Transplantationschirurgie
Frau Simone Abächerli (Clinical Nurse)
Rämistrasse 100
8091 Zürich